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RS-102221 

Cat. No. M28951

All AbMole products are for research use only, cannot be used for human consumption.

RS-102221  Structure

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Quality Control & Documentation
Biological Activity

RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats.

Chemical Information
Molecular Weight 612.62
Formula C27H31F3N4O7S
CAS Number 185376-97-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Layana Aquino de Moura, et al. Prog Neuropsychopharmacol Biol Psychiatry. Roles of the 5-HT2C receptor on zebrafish sociality

[2] Samah M Elaidy, et al. Pharmacol Rep. The antifibrotic effects of alveolar macrophages 5-HT2C receptors blockade on bleomycin-induced pulmonary fibrosis in rats

[3] E G Kuznetsova, et al. Bull Exp Biol Med. Effect of 5-HT2C receptor antagonist RS 102221 on mouse behavior

[4] D W Bonhaus, et al. Ann N Y Acad Sci. Absorption and brain penetration of a high affinity, highly selective 5-HT2C receptor antagonist, RS-102221

[5] D W Bonhaus, et al. Neuropharmacology. RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist

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  Catalog
Abmole Inhibitor Catalog




Keywords: RS-102221  supplier, 5-HT Receptor, inhibitors, activators

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