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Rozanolixizumab

Cat. No. M24723

All AbMole products are for research use only, cannot be used for human consumption.

Rozanolixizumab Structure
Synonym:

UCB7665

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100ug USD 170 In stock
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Biological Activity

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases. Rozanolixizumab binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd 23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab is observed to inhibit the recycling (IC50 0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner.

Chemical Information
CAS Number 1584645-37-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Deepak Menon, et al. Drugs. Pharmacotherapy of Generalized Myasthenia Gravis with Special Emphasis on Newer Biologicals

[2] Vera Bril, et al. Neurology. Efficacy and Safety of Rozanolixizumab in Moderate to Severe Generalized Myasthenia Gravis: A Phase 2 Randomized Control Trial

[3] Bryan Smith, et al. MAbs. Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration

[4] Peter Kiessling, et al. Sci Transl Med. The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study

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Keywords: Rozanolixizumab, UCB7665 supplier, inhibitors, activators

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