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Recently, Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. Mallatoxin tested on hERG channels increased both step and tail hERG current by leftward shifting the voltage dependence of hERG activation and slowing channel deactivation. These actions distinguish Mallatoxin as a novel naturally occurring hERG channel activator.
| Molecular Weight | 516.54 |
| Formula | C30H28O8 |
| CAS Number | 82-08-6 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Dittu Suresh, et al. Natural Product Rottlerin Derivatives Targeting Quorum Sensing
[2] Wan-Ling Huang, et al. Rottlerin, BDNF, and the impairment of inhibitory avoidance memory
[3] E Maioli, et al. Non-conventional rottlerin anticancer properties
[4] Emanuela Maioli, et al. Rottlerin and curcumin: a comparative analysis
[5] Stephen P Soltoff. Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta
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