All AbMole products are for research use only, cannot be used for human consumption.
Rosuvastatin (Crestor) is a member of the compound class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins.
Atherosclerosis. 2019 Nov;290:19-30.
Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α.
Rosuvastatin calcium purchased from AbMole
Pak J Pharm Sci. 2016 May;29(3 Suppl):1043-51.
Chromatographic resolution of drug analogues: 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins)
Rosuvastatin calcium purchased from AbMole
 |
Source | Pak J Pharm Sci (2016). Figure 1. Rosuvastatin calcium (Abmole Bioscience) |
| Method | HPLC chromatogram | |
| Cell Lines | ||
| Concentrations | 200μg/ml | |
| Incubation Time | ||
| Results | The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts. |
| Molecular Weight | 500.57 |
| Formula | C44H54CaF2N6O12S2 |
| CAS Number | 147098-20-2 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yvette N Lamb. Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia
[4] Gurpreet S Wander, et al. Rosuvastatin: Role in Secondary Prevention of Cardiovascular Disease
[5] Francesca Cortese, et al. Rosuvastatin: Beyond the cholesterol-lowering effect
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin sodium
Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Pravastatin sodium
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
| Lovastatin
Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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