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Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity. Roquinimex at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS blood when analysed in vitro.
| Molecular Weight | 308.33 |
| Formula | C18H16N2O3 |
| CAS Number | 84088-42-6 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Q Liu, et al. Inflamm Res. Roquinimex inhibits dextran sodium sulfate-induced murine colitis
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