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Rolitetracycline is a tetracycline antibiotic, which passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
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Source | Chem Biol Drug Des (2012). Figure 8. Rolitetracycline |
| Method | Fluorescence spectroscopy | |
| Cell Lines | ||
| Concentrations | 15 μM | |
| Incubation Time | ||
| Results | A sample containing 15 lM BSA was excited at 295 Nm, and emission was monitored at 344 nm. The decay curves fitted well to a bi-exponential function in the entire concentration range of the drugs studied. |
 |
Source | Chem Biol Drug Des (2012). Figure 6. Rolitetracycline |
| Method | scanning calorimetry | |
| Cell Lines | ||
| Concentrations | 0.09 mM | |
| Incubation Time | ||
| Results | In the presence of TC and RTC at drug to protein molar ratios from 1:1 to 10:1, broad endotherms are obtained (Figure 6), the deconvolution of which yields a best fit to two components unfolding at different temperatures |
| Cell Experiment | |
|---|---|
| Cell lines | 32D cl 3 cell |
| Preparation method | Antibiotic/Antifungal agents including cilastatin, amikacin, ceftazidine, vancomycin, tetracycline, doxycycline, ciprofloxacin, metronidazole, methacycline, minocycline, meclocycline, oxytetracycline and rolitetracycline were added in 1, 10, or 100 micromolar concentrations to murine interleukin-3-dependent hematopoietic progenitor cell line 32D cl 3 cells either before or after irradiation of 0 to 8 Gy. |
| Concentrations | 100 µM |
| Incubation time | 7 d |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 527.57 |
| Formula | C27H33N3O8 |
| CAS Number | 751-97-3 |
| Form | Solid |
| Solubility (25°C) | Water 10 mg/mL |
| Storage | Powder -20°C |
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