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Ro4368554

Cat. No. M8145

All AbMole products are for research use only, cannot be used for human consumption.

Ro4368554 Structure

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Biological Activity

Ro4368554 is a 5-HT6 receptor antagonist. RO4368554 acts selectively at 5-HT6 receptors where it binds with a greater than 100-fold selectivity over other monoamine receptor subtypes (-log M pKi = 9.4 at 5-HT6 and 7.1 at 5-HT2A).

Chemical Information
Molecular Weight 355.45
Formula C19H21N3O2S
CAS Number 478082-99-4
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ellen S Mitchell, et al. Adaptations in 5-HT receptor expression and function: implications for treatment of cognitive impairment in aging

[2] Stephen R Morairty, et al. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats

[3] Rudy Schreiber, et al. Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating

[4] Cindy K J Lieben, et al. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat

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Keywords: Ro4368554 supplier, inhibitors, activators

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