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Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response.
| Molecular Weight | 340.38 |
| Formula | C20H16N6 |
| CAS Number | 293762-45-5 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Tae-Joon Hong, et al. Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism
[5] Fang Guo, et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response
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