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Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Ro 67-7476 potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Ro 67-7476 displays no activity at human mGlu1 receptors.
| Molecular Weight | 319.39 |
| Formula | C17H18FNO2S |
| CAS Number | 298690-60-5 |
| Solubility (25°C) | DMSO 32 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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