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Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.
| Molecular Weight | 455.54 |
| Formula | C22H29NO2.C4H4O4 |
| CAS Number | 1312991-76-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL Water 4 mg/mL (warmed) |
| Storage | 4°C, dry, sealed |
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