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Elironrasib is an orally active and covalent inhibitor of KRASG12C(ON). Elironrasib prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. Elironrasib inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. Elironrasib also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM.
| Molecular Weight | 1012.26 |
| Formula | C55H78FN9O8 |
| CAS Number | 2641998-63-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | Powder -20°C |
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