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RK-701 

Cat. No. M29754

All AbMole products are for research use only, cannot be used for human consumption.

RK-701  Structure

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Quality Control & Documentation
Biological Activity

RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A.

Chemical Information
Molecular Weight 446.54
Formula C26H30N4O3
CAS Number 2648855-18-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Yosuke Nishigaya, et al. J Med Chem. Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents

[2] Shohei Takase, et al. Nat Commun. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

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  Catalog
Abmole Inhibitor Catalog




Keywords: RK-701  supplier, Histone Methyltransferase, inhibitors, activators

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