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Rineterkib (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF.
| Molecular Weight | 578.42 |
| Formula | C26H27BrF3N5O2 |
| CAS Number | 1715025-32-3 |
| Solubility (25°C) | DMSO ≥ 150 mg/mL |
| Storage | 4°C, protect from light, dry |
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