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Rimegepant, also known as BMS-927711, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist with a Ki value of 0.027 nM. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile. The compound is unstable in solutions, freshly prepared is recommended.
| Molecular Weight | 534.56 |
| Formula | C28H28F2N6O3 |
| CAS Number | 1289023-67-1 |
| Solubility (25°C) | DMSO 9 mg/mL Ethanol 9 mg/mL |
| Storage | -20°C |
| Related CGRP Receptor Products |
|---|
| MK-3207 hydrochloride
MK-3207 hydrochloride is a potent CGRP receptor antagonist with IC50 of 0.12 nM. |
| MK-0974
MK-0974 (Telcagepant) is a highly potent, selective and orally bioavailable CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors respectively. |
| BAR501
BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. |
| BAR 501 impurity |
| Olcegepant (BIBN-4096)
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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