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Riluzole is a compound used to study ALS. Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with impaired neurons. This reduces the influx of calcium ions and indirectly blocks the stimulation of glutamate receptors. Rilutek inhibits glutamate release from the presynaptic terminal and increases Na+ dependent glutamate uptake from synaptosomes in the rat cortex. It blocks voltage-dependent Na+ channels and inhibits GABA uptake by the synaptosomes of the striatum. Neuroprotection. Riluzole protects cultured neurons from hypoxia damage, toxic effects of glutamate uptake inhibitors, and toxic factors in the cerebrospinal fluid of isolated ALS patients. In vivo, riluzole has neuroprotective, anticonvulsant and sedative effects. Complete inhibition of ischemia-induced surges in glutamate release has been observed in a rodent model of transient global cerebral ischemia. Studies have shown that Riluzole (Rilutek) activates the Potassium ion channel TREK family, directly affecting the glutamate energy system.
| Molecular Weight | 234.2 |
| Formula | C8H5F3N2OS |
| CAS Number | 1744-22-5 |
| Solubility (25°C) | DMSO 60 mg/mL Ethanol 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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