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Rilpivirine hydrochloride

Cat. No. M30512

All AbMole products are for research use only, cannot be used for human consumption.

Rilpivirine hydrochloride Structure
Synonym:

TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride

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Quality Control & Documentation
Biological Activity

Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV.

Chemical Information
Molecular Weight 402.88
Formula C22H19ClN6
CAS Number 700361-47-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Elahe Taki, et al. Expert Rev Anti Infect Ther. Cabotegravir/Rilpivirine: the last FDA-approved drug to treat HIV

[2] Daryl Hodge, et al. Clin Pharmacokinet. Pharmacokinetics and Drug-Drug Interactions of Long-Acting Intramuscular Cabotegravir and Rilpivirine

[3] Edgar T Overton, et al. Lancet. Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study

[4] A Markham. Drugs. Cabotegravir Plus Rilpivirine: First Approval

[5] Susan Swindells, et al. N Engl J Med. Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

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Keywords: Rilpivirine hydrochloride, TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride supplier, Anti-infection, inhibitors, activators

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