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Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist.
| Cell Experiment | |
|---|---|
| Cell lines | Platelet-rich plasma samples |
| Preparation method | Lp-PLA2 activity was measured in parallel using plasma samples that were derived from PRP that had been treated either with vehicle or rilapladib (100 nM) for 5 minutes using [3H]-PAF as the substrate as previously described. |
| Concentrations | 100 nM |
| Incubation time | 5 minutes |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 735.8 |
| Formula | C40H38F5N3O3S |
| CAS Number | 412950-08-4 |
| Solubility (25°C) | DMSO 78 mg/mL |
| Storage | Powder -20°C |
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