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Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB).
| Molecular Weight | 941.07 |
| Formula | C51H64N4O13 |
| CAS Number | 129791-92-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 8 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
[2] No authors listed. Tuberculosis (Edinb). Rifalazil
[5] David M Rothstein, et al. Expert Opin Investig Drugs. Development potential of rifalazil
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