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RHPS 4 methosulfate is a telomerase inhibitor. RHPS 4 inhibits growth of medulloblastoma and glioblastoma cells in vitro. RHPS 4 induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice.
| Molecular Weight | 458.48 |
| Formula | C22H17F2N2.CH3O4S |
| CAS Number | 390362-78-4 |
| Solubility (25°C) | DMSO 9.17 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Telomerase Products |
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| MST-312
MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG) and a telomerase inhibitor. It can be used in the study of tumors such as multiple myeloma (MM). |
| Cycloastragenol
Cycloastragenol (Astramembrangenin) is the active form of Astragaloside IV and has antioxidant, anti-inflammatory, anti-aging, anti-apoptotic and cardiovascular protective effects. Cycloastragenol is an effective telomerase activator that lengthens telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties. |
| 360A iodide
360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay. |
| Epitalon
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa. |
| Ceramides
Ceramides, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides is a main lipid component of the permeability barrier in epidermis. |
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