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Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM[1]. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM.
| Molecular Weight | 610.52 |
| Formula | C27H30O16 |
| CAS Number | 86831-54-1 |
| Solubility (25°C) | DMSO ≥ 24 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
[5] Wen Xu, et al. Pharmazie. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea
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