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Rhodionin was isolated from the roots of Rhodiola crenulata and is a specific non-competitive cytochrome P450 2D6 inhibitor with IC50 of 0.761 μM and Ki of 0.769 μM. Rhodionin effectively inhibited acetylcholinesterase (AChE) in a dose-dependent manner with an IC50 range of 57.50 to 2.43 μg/mL. Rhodionin had effective DPPH radical scavenging activity with IC50 of 19.49 μM.
| Molecular Weight | 448.38 |
| Formula | C21H20O11 |
| CAS Number | 85571-15-9 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[3] Wen Xu, et al. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea
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