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RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
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Source | Sci Rep (2018). Figure 1. RGD |
| Method | measuring fluorescence intensity | |
| Cell Lines | U87MG and K562 cells | |
| Concentrations | 200 nM | |
| Incubation Time | 7 h | |
| Results | Figure 2a shows cellular uptake of PSs at various concentrations in U87MG cells. The 700DX-PEG-cRGD, 700DX-PEG-PGlu-cRGD5, and 700DX-PEG-PGlu-cRGD15 revealed significantly high cellular uptake depending on the number of cRGD peptides, while no significant difference could be obtained between free 700DX and 700DX-PEG-PGlu-cRAD15. |
| Molecular Weight | 346.34 |
| Formula | C12H22N6O6 |
| CAS Number | 99896-85-2 |
| Solubility (25°C) | Water 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Meng Yang, et al. Function and Mechanism of RGD in Bone and Cartilage Tissue Engineering
[4] Sotirios Katsamakas, et al. RGD-mediated delivery of small-molecule drugs
[5] E Ruoslahti. RGD and other recognition sequences for integrins
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