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RG7800

Cat. No. M11535

All AbMole products are for research use only, cannot be used for human consumption.

RG7800 Structure
Synonym:

RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247

Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 110 In stock
25mg USD 220 In stock
50mg USD 280 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

RG7800 is a small molecule SMN2 splicing modifier. RG7800 has the potential to be used in spinal muscular atrophy. RG7800 corrects selective splicing of the human SMN2 gene in the brain of a transgenic SMA model mouse, leading to an increase in SMN protein in the brain.

Chemical Information
Molecular Weight 416.52
Formula C24H28N6O
CAS Number 1449598-06-4
Solubility (25°C) DMSO:1.4 mg/mL
Storage 4-8°C
References

[1] Kaitlyn M Kray, et al. Neurobiol Dis. Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice

[2] Renske I Wadman, et al. Cochrane Database Syst Rev. Drug treatment for spinal muscular atrophy types II and III

[3] Alyssa N Calder, et al. J Med Chem. Small Molecules in Development for the Treatment of Spinal Muscular Atrophy

[4] Hasane Ratni, et al. J Med Chem. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy

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Keywords: RG7800, RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247 supplier, DNA/RNA Synthesis, inhibitors, activators

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