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Retrorsine is a naturally occurring pyrrolizidine alkaloid, which binds with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine significantly reduces HSEC-CYP3A4 cells viability, depletes GSH, and increases formation of pyrrole-protein adducts. Retrorsine (30 mg/kg; i.p.) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle.
| Molecular Weight | 351.39 |
| Formula | C18H25NO6 |
| CAS Number | 480-54-6 |
| Solubility (25°C) | Soluble in CHCL3 |
| Storage | -20°C, dry, sealed, protect from light |
| Related Alkaloids Products |
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| Homoharringtonine
Homoharringtonine is a cephalotaxine alkaloid which inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. |
| Yunaconitine
Yunaconitine |
| Peimine
Peimine is a natural compound with good anti-inflammatory effects in vivo. |
| Solamargine
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicinal herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells. |
| Gelsenicine
Gelsenicine |
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