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Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).
Retatrutide acetate inhibits for human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide acetate has efficacy for mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively.
Retatrutide (LY3437943) acetate engages GCGR in vivo and can improve glucose tolerance in an ipGTT through either the GIP or GLP-1 receptors. Retatrutide acetate causes great body weight loss and increases energy expenditure through glucagon receptor activatio. Retatrutide acetate can be used for the research of obesity.
| Molecular Weight | 4791.38 |
| Formula | C221H342N46O68.C2H4O2 |
| CAS Number | 2381089-83-2 (free base) |
| Form | Solid |
| Solubility (25°C) | Water 10 mg/mL |
| Storage | Store at ≤ -20°C, protect from light, dry, sealed |
| Related Glucagon Receptor Products |
|---|
| PF-06291874
PF-06291874 is an orally active, potent and selective glucagon receptor antagonist. |
| GRA Ex-25
GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 values of 56 and 55 nM for rat and human glucagon receptors, respectively. |
| Glucagon (1-29), bovine, human, porcine
Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation. |
| NNC0640
NNC0640 is a potent, negative allosteric modulator (NAM) of human G-protein-coupled glucagon receptor (GCGR) with IC50 of 69.2 nM. |
| Dasiglucagon acetate
Dasiglucagon acetate is a Glucagon Receptor Agonist. The physiologic effect of dasiglucagon is by means of Increased Glycogenolysis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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