All AbMole products are for research use only, cannot be used for human consumption.
Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Resveratrol slightly inhibited ethoxyresorufin O-deethylation (EROD) activity in human liver microsomes with an IC50 of 1.1 mM. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
Tumor growth in a xenograft model
Female BALB/c (nu/nu) mice, 6 weeks old, were housed in a light/dark cycle of 12/12 h and fed with rodent chow and water ad libitum. PA-1 cells (1 × 10^7 in 200 uL PBS) were injected s.c. on the right hind flank. Tumor volume (length × width × depth × 0.52) was measured three times a week. After 10 days of implantation, two groups (n = 10) were given resveratrol (dissolved in 5% ethanol and 25% polyethyleneglycol 400 in distilled water) i.p. at a daily dose of 50 or 100 mg/kg body weight for consecutive 4 weeks, whereas the other group received the vehicle only. Body weights were recorded everyday.
https://pubmed.ncbi.nlm.nih.gov/19738051/
Biomaterials. 2025 Aug;319:123208.
Bio-orthogonal-labeled exosomes reveals specific distribution in vivo and provides potential application in ARDS therapy
Resveratrol purchased from AbMole
Biomaterials. 2025 Feb 24;319:123208.
Bio-orthogonal-labeled exosomes reveals specific distribution in vivo and provides potential application in ARDS therapy
Resveratrol purchased from AbMole
Molecules. 2023 Apr 7.
Study of the Sensing Kinetics of G Protein-Coupled Estrogen Receptor Sensors for Common Estrogens and Estrogen Analogs
Resveratrol purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | CNE-1 and CNE-2Z cells |
| Preparation method | Cell proliferation assay The effect of resveratrol on the cell growth of CNE-1 and CNE-2Z cells was examined using the MTT assay. Cancer cells were plated in 96-well plates at 104 cells/well. Following pretreatment with different concentrations of resveratrol for 24 or 48 h, viable cells were determined using the MTT Assay kit (Chemicon, Temecula, CA, USA) according to the manufacturer’s protocol. At indicated time-points, 20 μl of MTT solution (5 mg/ml in PBS) were added into each well and incubated for 4 h. Then, 100 μl of DMSO was added to dissolve the crystals. The plate was then left to stand for 10 min at room temperature and the corresponding absorbance was measured at 490 nm. Each experiment was performed in triplicate. |
| Concentrations | 0, 10, 25, 50 and 100 μM |
| Incubation time | 24 or 48 h |
| Animal Experiment | |
|---|---|
| Animal models | female nude mice bearing CNE-2Z tumour xenograft model |
| Formulation | 10% DMSO in PBS |
| Dosages | 20 mg/kg once a day for 3 weeks |
| Administration | i.p. |
| Molecular Weight | 228.24 |
| Formula | C14H12O3 |
| CAS Number | 501-36-0 |
| Solubility (25°C) | DMSO 60 mg/mL Ethanol 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Sirtuin Products |
|---|
| Selisistat
Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| SRT1720 Hydrochloride
SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| Balsalazide disodium
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis. |
| Sirtinol
Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
| Ganoderic-acid-D
Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
