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Reproxalap

Cat. No. M30897

All AbMole products are for research use only, cannot be used for human consumption.

Reproxalap Structure
Synonym:

ADX-102; NS-2

Size Price Availability Quantity
10mM*1mL in DMSO USD 70 In stock
10mg USD 60 In stock
25mg USD 125 In stock
50mg USD 210 In stock
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Biological Activity

Reproxalap (ADX-102) is a reactive aldehyde species (RASP) sequestering agent for the treatment of dry eye. Reproxalap (ADX-102) covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal.

Chemical Information
Molecular Weight 236.7
Formula C12H13ClN2O
CAS Number 916056-79-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bill Cavanagh, et al. Ophthalmol Ther. Reproxalap Activity and Estimation of Clinically Relevant Thresholds for Ocular Itching and Redness in a Randomized Allergic Conjunctivitis Field Trial

[2] David Clark, et al. Clin Ophthalmol. Reproxalap Improves Signs and Symptoms of Allergic Conjunctivitis in an Allergen Chamber: A Real-World Model of Allergen Exposure

[3] David Clark, et al. Am J Ophthalmol. Clinically Relevant Activity of the Novel RASP Inhibitor Reproxalap in Allergic Conjunctivitis: The Phase 3 ALLEVIATE Trial

  Catalog
Abmole Inhibitor Catalog




Keywords: Reproxalap, ADX-102; NS-2 supplier, RASP, inhibitors, activators

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