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Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer.
| Cell Experiment | |
|---|---|
| Cell lines | PBMCs |
| Preparation method | Total PBMCs from patients with CLL were treated with Relatlimab or control IgG (10 μg/mL) for 72 h. |
| Concentrations | 10 μg/mL |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | Female C57BL/6 mice |
| Formulation | Saline |
| Dosages | 100 mg/kg |
| Administration | Intravenous injection |
| CAS Number | 1673516-98-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Lewis Au, et al. Cell. Relatlimab and nivolumab in the treatment of melanoma
[2] Rodabe N Amaria, et al. Nature. Neoadjuvant relatlimab and nivolumab in resectable melanoma
[4] Julia Paik. Drugs. Nivolumab Plus Relatlimab: First Approval
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