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CXCL2/CINC-2, also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.
A DNA sequence encoding the rat Cxcl2 (NP_446099.1) (Ser32-Asn100) was expressed with two additional amino acids (Gly & Pro ) at the N-terminus.
The recombinant rat Cxcl2 consists 69 amino acids and predicts a molecular mass of 7.6 kDa.
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.
| Storage | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
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