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The stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. SDF-1/CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism.
A DNA sequence encoding the mature form of mouse SDF-1 (Lys22-Lys89) was expressed and purified with an initial Met.
The recombinant mouse SDF-1 consists of 69 amino acids and predicts a molecular mass of 8.1 KDa. It migrates as an approximately 8 KDa band in SDS-PAGE under reducing conditions.
Accession: P40224
Endotoxin: < 1.0 EU per μg protein as determined by LAL test
Lyophilized from sterile 50% acetonitrile, 1% TFA.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile water up to 150 μg/ml. |
| Storage | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
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