All AbMole products are for research use only, cannot be used for human consumption.
In vivo, PDGF-BB is mainly produced in the heart and placenta and is mainly expressed by osteoblasts, fibroblasts, smooth muscle cells and glial cells. Inactive precursors of PDGF-BB are produced in the endoplasmic reticulum and then secreted and activated by proteinogen invertase. Pdgf-bb plays a paracrine role in promoting organogenesis, bone development and wound healing. Pdgf-bb also promotes angiogenesis, especially in the presence of basic fibroblast growth factor. Therefore, PDGF-BB and its related pathways are potential pharmacological targets.
Recombinant Mouse PDGF-BB expressed the target gene encoding Ser82-Thr190.
Measured by a cell proliferation assay using 3T3 cells, the ED50 is < 2.5 ng/ml, corresponding to a specific activity of > 4.0 × 105 units/mg.
Accession: P31240
Endotoxin < 0.2 EU/µg
Apparent Molecular Weight: ~24.7 KDa, reducing conditions
Lyophilized after extensive dialysis against 10 mM sodium citrate, pH 3.0.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[2] S Vogel, et al. Biochemistry. Binding domains and epitopes in platelet-derived growth factor
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