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Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. It is essential in the pathway that leads to type I immunity. Osteopontin has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The fact that SPP1 interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation and ischemia.
Recombinant Mouse Osteopontin/SPP1 expressed the target gene encoding Leu17-Asn294 with His tag at the C-terminus.
Measured by the ability of the immobilized protein to support the adhesion of human embryonic kidney cells (HEK293), cell adhesion is enhanced in a dose-dependent manner after 1 hour incubation at 37 ℃, the ED50 for this effect is 0.25-1.5 µg/mL.
Accession: Q547B5
Endotoxin < 0.1 EU/μg
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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