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Recombinant Mouse IL-33 Protein (E. coli, 95%)

Cat. No. M31329

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse IL-33 Protein (E. coli, 95%) Structure
Synonym:

Interleukin 33

Size Price Availability Quantity
10ug USD 220 In stock
50ug USD 560 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.01 EU/μg
  • COA
  • MSDS
Biological Activity

Mouse Interleukin 33 (IL-33) may regulates gene transcription in producer cells. IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. The target gene encoding Ser109-Ile266 is expressed.

Recombinant Mouse Interleukin-33 expressed the target gene encoding Ser109-Ile266.

Immobilized Mouse IL-33 at 5μg/ml (100 μl/well) can bind Mouse ST2-Fc, the ED50 of Mouse ST2-Fc is 0.33 ug/ml.


Accession: Q8BVZ5

Apparent Molecular Weight: 18 KDa, reducing conditions

Endotoxin: < 0.01 EU/μg

Lyophilized from a 0.2 μm filtered solution of PBS, 1mM DTT, pH 7.4.

Product Citations
Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Yunxian Li, et al. Bioengineering (Basel). Recombinant Expression of Human IL-33 Protein and Its Effect on Skin Wound Healing in Diabetic Mice

[2] Olga S Blomberg, et al. Cancer Cell. IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

[3] Yankai Wen, et al. Hepatology. Interleukin-33 facilitates liver regeneration through serotonin-involved gut-liver axis

[4] Alexandra Schröder, et al. Allergy. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33

[5] Shun-Fat Lau, et al. Cell Rep. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease

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