All AbMole products are for research use only, cannot be used for human consumption.
Interleukin-15 (IL-15) is a 14-15 kDa glycoprotein with immune regulatory functions in many diverse cell types. As a pleiotropic cytokine, IL-15 mediates the crosstalk between innate immunity and adaptive immunity whose principal role is to kill virally infected cells. IL-15 plays a crucial role in the development, differentiation, and survival of NK cells. In monocytes, IL-15 induces the production of IL-8 and monocyte chemotactic protein 1 (MCP-1), which recruits neutrophils and monocytes to sites of infection. IL-15 can also act as a chemo-attractant in T lymphocytes and regulate the differentiation of T lymphocytes.
Measure by its ability to induce CTLL-2 cells proliferation, the ED50 for this effect is <10 ng/mL. The specific activity of recombinant mouse IL-15 is approximately >1x 105 IU/mg.
Sequence: NWIDVRYDLE KIESLIQSIH IDTTLYTDSD FHPSCKVTAM NCFLLELQVI LHEYSNMTLN ETVRNVLYLA NSTLSSNKNV AESGCKECEE LEEKTFTEFL QSFIRIVQMF INTS with polyhistidine tag at the N-terminus.
Accession: P48346
Apparent Molecular Weight: 17 kDa, reducing conditions
Endotoxin < 0.1 EU/µg
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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