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CNTF is an effective survival factor for neurons and oligodendrocytes and may play a role in reducing tissue damage when inflammation increases. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracellular CNTF binding subunit (CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocyteands may be relevant in reducing tissue destruction during inflammatory attacks.
The recombinant mouse CNTF consists of 215 amino acids and predicts a molecular mass of 24.7 KDa. A DNA sequence encoding the mouse CNTF (Ala2-Met198) is expressed with a polyhistidine tag at the N-terminus.
Measured by its binding ability in a functional ELISA, immobilized mouse CNTF at 10 μg/ml (100 μl/well) can bind biotinylated rat CNTFR-His.
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 25 KDa, reducing conditions
Lyophilized from sterile PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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