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Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures.
Recombinant Mouse BMP-4 expressed the target gene encoding Ser293-Arg408 with polyhistidine tag at the C-terminus.
Measure by its ability to induce alkaline phosphatase production by ATDC5 cells, the ED50 for this effect is <10 ng/mL, the specific activity of recombinant mouse BMP-4 is > 1 x 105 IU/mg.
Accession: P21275
Apparent Molecular Weight: 11-17 kDa, under reducing conditions
Endotoxin < 0.1 EU/µg
Lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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