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Recombinant Mouse Beta-NGF Protein (110AA, E. coli)

Cat. No. M11232

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse Beta-NGF Protein (110AA, E. coli) Structure
Synonym:

β-NGF; NGFB

Size Price Availability Quantity
10ug USD 125 In stock
50ug USD 250 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin <1 EU/μg
  • COA
  • MSDS
Biological Activity

Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.

Measured by the cell proliferation assay using TF‑1 human erythroleukemic cells, the ED50 for this effect is 68.52 ng/ml.


Accession: P01139

APMol Mass: 13 KDa, reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, pH 8.0.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months.
References

[1] Kevin O Rivera, et al. Sci Rep. Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion

[2] Caroline Pinet-Charvet, et al. Sci Rep. Beta-nerve growth factor stimulates spontaneous electrical activity of in vitro embryonic mouse GnRH neurons through a P75 mediated-mechanism

[3] Jun Yuan, et al. Mol Cell Biochem. Overexpression of β-NGF promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathway

[4] G Heinrich, et al. Biochem Biophys Res Commun. Nerve growth factor (NGF) is present in human placenta and semen, but undetectable in normal and Paget's disease blood: measurements with an anti-mouse-NGF enzyme immunoassay using a recombinant human NGF reference

[5] L A Cunningham, et al. Exp Neurol. Survival and differentiation within the adult mouse striatum of grafted rat pheochromocytoma cells (PC12) genetically modified to express recombinant beta-NGF

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Keywords: Recombinant Mouse Beta-NGF Protein (110AA, E. coli), β-NGF; NGFB supplier, Cytokines and Growth Factors, inhibitors, activators

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