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TGFBR2 is a uniplex type I membrane protein containing a protein kinase domain. TGFBR2 exists as a heterodimer complex with another receptor protein and binds to TGF - β. Signals triggered by TGF - β receptor complexes trigger various cellular responses. One response is to inhibit cell growth and division. Based on this effect, TGF - β receptor type 2 is sometimes referred to as a tumor suppressor. Defects in TGFBR2 are associated with the development of Marfan syndrome, Loys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and various tumor types.
Recombinant Human TGFBR2 expressed the target gene encoding Thr23-Asp159 with a human IgG1 Fc tag at the C-terminus.
Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells, the ED50 for this effect is 18.41 ng/ml in the presence of 100pg/ml of recombinant human TGF-beta 1.
Accession: P37173
Apparent Molecular Weight: 59 KDa, reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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