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Recombinant Human TGF-beta 1 (HEK293)

Cat. No. M15086

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human TGF-beta 1 (HEK293) Structure
Synonym:

Transforming Growth Factor Beta-1; TGF-Beta-1

Size Price Availability Quantity
10ug USD 225 In stock
50ug USD 700 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 0.01 EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human TGF-beta 1 (TGFβ-1) performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members.

Measured by its ability to inhibit the IL-4-dependent proliferation of TF‑1 human erythroleukemic cells, the ED50 is 4-40 pg/ml.

Recombinant Human Transforming Growth Factor Beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed.


Accession: P01137

APMol Mass: 13 KDa, reducing conditions

Endotoxin: < 0.01 EU/µg as determined by LAL test

Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months.
References

[1] Jun Li, et al. Kaohsiung J Med Sci. Circ_0001666 upregulation promotes intestinal epithelial cell fibrosis in pediatric Crohn's disease via the SRSF1/BMP7 axis

[2] Musubu Takahashi, et al. Int J Mol Sci. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β 1: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways

[3] Sean K Wang, et al. J Clin Invest. Microglia modulation by TGF-β1 protects cones in mouse models of retinal degeneration

[4] June-Hyung Kim, et al. Cell Death Dis. TTC3 contributes to TGF-β 1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation

[5] Mohammad M Al-Qattan, et al. J Coll Physicians Surg Pak. Effect of TGFβ1 and nAG on Astrocyte Cultures: A Study of Astrocyte Proliferation and the Expression of GFAP, CSPG4, S100B and IL-6

[6] Senem Aykul, et al. Anal Biochem. Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis

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Keywords: Recombinant Human TGF-beta 1 (HEK293), Transforming Growth Factor Beta-1; TGF-Beta-1 supplier, Cytokines and Growth Factors, inhibitors, activators

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