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Recombinant Human STC-1 (HEK293, C-6His)

Cat. No. M22454

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human STC-1 (HEK293, C-6His) Structure
Synonym:

Stanniocalcin 1

Size Price Availability Quantity
10ug USD 200 In stock
50ug USD 535 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. STC-1 inhibits the breakdown of PAPP-A, protects cancer cells from apoptosis, reduces tumor size of liver cancers, promotes osteoblast differentiation and inhibits longitudinal bone growth directly at the growth plate. STC-1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation.


Accession: P52823

APMol Mass: 28-36 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt
References

[1] Kotaro Abe, et al. Cancer Med. Targeting stanniocalcin-1-expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer

[2] Myeongjin Jeon, et al. Oncol Rep. STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells

[3] Jeonghun Han, et al. Oncol Rep. Elevated STC‑1 augments the invasiveness of triple‑negative breast cancer cells through activation of the JNK/c‑Jun signaling pathway

[4] Xin Shi, et al. J Cardiovasc Pharmacol. Recombinant adeno-associated virus-delivered hypoxia-inducible stanniocalcin-1 expression effectively inhibits hypoxia-induced cell apoptosis in cardiomyocytes

[5] Joseph P Ellard, et al. Mol Cell Endocrinol. The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates

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Keywords: Recombinant Human STC-1 (HEK293, C-6His), Stanniocalcin 1 supplier, Cytokines and Growth Factors, inhibitors, activators

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