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Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell.
Recombinant Human Sialic Acid-binding Ig-like Lectin 10 expressed the target gene encoding Met17Thr546 with a human IgG1 Fc tag at the C-terminus.
The ED50 of Human Siglec-10-Fc is 9.18 ng/ml.
Accession: Q96LC7
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 110-120 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 6% Sucrose, 4% Mannitol, 50mM NaCl, 0.05% Tween 80, pH 8.0.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Related Receptor Proteins Products |
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| Recombinant Human Siglec-15 Protein (HEK293, C-Fc)
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| Recombinant Human Siglec-15 Protein (HEK293, C-mFc)
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| Recombinant Human Siglec-9 Protein (HEK293, C-Fc)
Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes, and found in liver, fetal liver, bone marrow, placenta, spleen and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. |
| Recombinant Human Siglec-6 Protein (HEK293, C-Fc)
Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. |
| Recombinant Human SIGLEC-10 Protein (HEK293, His Tag)
The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
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