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Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling.
SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Recombinant Human Sclerostin expressed the target gene encoding Gln24-Tyr213 with a 6His tag at the C-terminus.
Accession: Q9BQB4
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 30 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 250mM NaCl, pH 8.0.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[2] Fuming Zhang, et al. Glycoconj J. Interactions between Sclerostin and Glycosaminoglycans
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Products are for research use only. Not for human use. We do not sell to patients.
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