All AbMole products are for research use only, cannot be used for human consumption.
Activity: Fixed human PD-L1(His tag) at a concentration of 5μg/mL (100 μL/ well) can bind human PD-1(Fc tag) in a linear range of 0.0625-1ug/mL.
Expression host: human HEK293 cells
Molecular weight: Recombinant human PD-1 protein contains 380 amino acids and has a predicted molecular weight of 43.4 kD.
Purity: ≥95% Was analyzed by SDS-PAGE gel and HIGH performance liquid chromatography.
Endotoxin: < 0.1EU/μg.
Stability: Freeze-dried samples can be stored at 4℃ for 24 months, dissolved liquid can be stored at -20℃ for 6-12 months, and avoid repeated freeze-thaw.
Programmed cell death protein 1 (PD-1), also known as CD279 and PDCD1, is a type I membrane protein that is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, bone marrow cells and thymocyte subsets. Pd-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. Pd-l1 is expressed in almost all mouse tumor cell lines, including PA1 myeloma, P815 mast cell tumor, and B16 melanoma, after treatment with IFN-γ. Pd-l2 expression was more restricted and was mainly expressed by DC and a few tumor lines. PD1 inhibits T cell proliferation and related cytokine production, including IL-1, IL-4, IL-10 and IFN-γ, by inhibiting the activation and transduction of PI3K/AKT pathway.
| Solubility (25°C) | ddH2O or PBS |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Qingqing Xiao, et al. Acta Pharm Sin B. Biological drug and drug delivery-mediated immunotherapy
[5] Y Latchman, et al. Nat Immunol. PD-L2 is a second ligand for PD-1 and inhibits T cell activation
| Related Cytokines and Growth Factors Products |
|---|
| Recombinant Human HGF (CHO-expressed)
Recombinant human Hepatocyte Growth Factor (rhHGF) , also known as hepatopoietin-A and scatter factor, is a pleiotropic mitogen belonging to the peptidase S1 family (plasminogen subfamily). It is produced by mesenchymal cells and acts on epithelial cells, endothelial cells and haemopoietic progenitor cells. |
| Recombinant Human RIPK3 Protein (E. coli, N-His)
RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. RIPK3 promotes kidney tubular injury via mitochondrial dysfunction. The FAO-dependent RIPK3 mediates pathogenesis of acute lung injury. |
| Recombinant Influenza B Hemagglutinin/HA Protein (HEK293, C-His)
Recombinant Influenza B Hemagglutinin / HA Protein is a homotrimer that recognizes target cells in vertebrates and does so by binding to salivary acid-containing receptors on these cells. When it binds to the target cell, it causes the host inner membrane to fuse with the viral membrane, thereby facilitating the entry of the viral genome into the target cell. |
| Recombinant Human FGF-9 (E. coli)
Fibroblast Growth Factor-9 (FGF-9) is a heparin binding growth factor that belongs to the fibroblast growth factor (FGF) family. ED50 < 2.0 ng/ mL, determined by 3T3 cell proliferation assay, corresponding to > 5.0× 105 units/mg. |
| Recombinant Human CXCL13/BCA-1 (E. coli)
CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
