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Recombinant Human OLR1/LOX1 (HEK293, C-6His)

Cat. No. M21445

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human OLR1/LOX1 (HEK293, C-6His) Structure
Synonym:

Oxidized Low-Density Lipoprotein Receptor 1; LOX-1

Size Price Availability Quantity
10ug USD 168 In stock
50ug USD 360 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as LOX1, is a receptor protein that belongs to the C-type lectin superfamily. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. Ox-LDL receptor 1 is expressed at high levels in endothelial cells and vascular rich organs such as placenta, lung, liver, brain, intima of the aorta, bone marrow, spinal cord and substantia nigra. Ox-LDL receptor 1 expression is induced by inflammatory cytokines such as TNF, IFNG, and IL6 in the context of hyperlipidemia, hypertension, and diabetes. Ox-LDL receptor-1 mediates the recognition, internalization, and degradation of oxidation-modified low-density lipoproteins (OxLDL) by vascular endothelial cells.

Recombinant Human OLR1/LOX1 expressed the target gene encoding Ser61-Gln273 with a 6His tag at the C-terminus.


Accession: P78380

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 30-35 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Tiancheng Zhao, et al. Cell Death Dis. Knockdown of OLR1 weakens glycolytic metabolism to repress colon cancer cell proliferation and chemoresistance by downregulating SULT2B1 via c-MYC

[2] Luigi Scietti, et al. Sci Rep. Exploring host-pathogen interactions through genome wide protein microarray analysis

[3] Yifan Qian, et al. Glycoconj J. Site-specific N-glycosylation identification of recombinant human lectin-like oxidized low density lipoprotein receptor-1 (LOX-1)

[4] Tiantai Zhang, et al. J Biotechnol. The expression of recombinant human LOX-1 and identifying its mimic ligands by fluorescence polarization-based high throughput screening

[5] Bertram Pitt. Circulation. A new HOPE for aldosterone blockade?

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Keywords: Recombinant Human OLR1/LOX1 (HEK293, C-6His), Oxidized Low-Density Lipoprotein Receptor 1; LOX-1 supplier, Cytokines and Growth Factors, inhibitors, activators

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