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NRG1 (pro-neuregulin-1, Neuregulin-1 beta 1) is a single-pathway type I membrane protein belonging to the Neuregulin family, which contains an EGF-like domain and an IG-LIKE C2 (immunoglobulin like) domain. The direct ligand of ERBB3 and ERBB4 tyrosine kinase receptors. This protein recruits both ERBB1 and ERBB2 co-receptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of ERBB receptors. Multiple subtypes have multiple functions, such as inducing the growth and differentiation of epithelial cells, glial cells, neuronal cells and skeletal muscle cells; The expression of acetylcholine receptors in synaptic vesicles during the formation of neuromuscular junctions stimulates alveolar budding and lactation induces differentiation of breast tumor cells and stimulates proliferation of Schwann cells. Associated with cardiac muscle development, such as trabecular formation of the developing heart. Isoform 10 May play a role in the development of motor and sensory neurons.
Recombinant Human Neuregulin-1 Beta expressed the target gene encoding Ser2-Lys246.
Accession: AAA58639.1
Apparent Molecular Weight: 34 KDa, under reducing conditions
Endotoxin < 0.01 EU/µg
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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