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Recombinant Human Noggin Protein (HEK293) can bind to ligands of the transforming growth factor-β family and regulate its activity by inhibiting its pathway with signal receptors. Noggin was initially identified as a BMP-4 antagonist, and its effect is essential for the normal formation of the head and other back structures. Therefore, noggin has been shown to regulate the activities of other BMP-2, -7, -13 and -14. Transgenic mice overexpress noggin in mature osteoblasts, which is manifested by impaired differentiation of osteoblasts, decreased bone formation, and severe osteoporosis.
Determined by the ability of ATDC chondrocytes to inhibit the production of alkaline phosphatase by 5.0 ng/ml BMP-4, the expected ED50 of this effect is about 2.0-3.0 ng/ml.
The DNA sequence encoding human noggin (NP_005441.1) is expressed with a His tag at the C terminus.
Recombinant human noggin contains 211 amino acids and has a predicted theoretical molecular weight of 23.9 kd.
Endotoxin ≤0.01EU/ug
Patent. CN119639678A 2025 Mar 18.
Patent. CN119639678A
Recombinant Human Noggin Protein (HEK293, C-His) purchased from AbMole
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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