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Recombinant Human Nesfatin-1 (E. coli)

Cat. No. M10431

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human Nesfatin-1 (E. coli) Structure
Synonym:

rHuNesfatin-1; Nucleobindin-2

Size Price Availability Quantity
10ug USD 280 In stock
50ug USD 740 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Nesfatin is a metabolic polypeptide and is the N-terminal region of the precursor protein, Nucleobindin2 (encoded by NUCB2 gene). Nesfatin-1 is a naturally occurring protein and originally identified as a hypothalamic neuropeptide. Additionally, Nesfatin can be found in other areas of brain, and in pancreatic isletsβ-cells, gastric endocrine cells and adipocytes. It is responsible for regulating appetite and production of body fat. A lack of nesfatin-1 in the brain leads to an increase of appetite, more frequent episodes of hunger, an increase of body fat and weight, and the inability to 'feel full'.

Recombinant Human Nesfatin-1 expressed the target gene encoding Val25-Leu106.


Accession: P80303

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 10 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 10mM Sodium Phosphate, pH 6.5.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Mingchen Li, et al. J Biol Res (Thessalon). Nesfatin-1 protects H9c2 cardiomyocytes against cobalt chloride-induced hypoxic injury by modulating the MAPK and Notch1 signaling pathways

[2] Tiemo Friedrich, et al. Int J Mol Sci. Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1

[3] Gokcen Guvenc-Bayram, et al. Neuropeptides. The involvement of the central cholinergic system in the hyperventilation effect of centrally injected nesfatin-1 in rats

[4] Vi Pham, et al. Am J Physiol Regul Integr Comp Physiol. Nesfatin-1 Stimulates the Hypothalamus-Pituitary-Interrenal Axis Hormones in Goldfish

[5] Jing-Jing Luo, et al. Clin Chim Acta. Nesfatin-1 in lipid metabolism and lipid-related diseases

[6] Ayelen M Blanco, et al. Front Endocrinol (Lausanne). Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

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Keywords: Recombinant Human Nesfatin-1 (E. coli), rHuNesfatin-1; Nucleobindin-2 supplier, Other Proteins, inhibitors, activators

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