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Recombinant Human MMP-9 (HEK293, C-6His)

Cat. No. M21336

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human MMP-9 (HEK293, C-6His) Structure
Synonym:

Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase

Size Price Availability Quantity
10ug USD 270 In stock
50ug USD 700 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Genus: Human
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 77.4 KDa
Storage and Stability: Stored at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months after opening under sterile conditions. Please minimize the freeze-thaw cycle


Bioactivity: Matrix metallopeptidase 9 (MMP-9) is an enzyme encoded by the MMP9 gene. This protein is produced by normal alveolar macrophages and granulocytes, is activated by 4-aminophenylmercaptoacetate and sorbitol esters in colorectal tumor cells, and is upregulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway.MMP-9 is involved in the breakdown of extracellular matrix during normal physiological processes such as embryonic development, reproduction, angiogenesis, skeletal development, wound healing cell migration, learning and memory, and also in pathological processes such as arthritis, intracerebral hemorrhage and metastasis.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mi-Lyang Kim, et al. Invest Ophthalmol Vis Sci. Statins Suppress TGF-β2-Mediated MMP-2 and MMP-9 Expression and Activation Through RhoA/ROCK Inhibition in Astrocytes of the Human Optic Nerve Head

[2] Haodi Dong, et al. Cell Prolif. Overexpression of matrix metalloproteinase-9 in breast cancer cell lines remarkably increases the cell malignancy largely via activation of transforming growth factor beta/SMAD signalling

[3] Arturo Flores-Pliego, et al. PLoS One. Matrix Metalloproteinase-3 (MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor

[4] Piotr Golab, et al. Neurol Res. The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activities in vitro

[5] Veronica C Ardi, et al. Proc Natl Acad Sci U S A. Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis

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Keywords: Recombinant Human MMP-9 (HEK293, C-6His), Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase supplier, Enzymes & Regulators, inhibitors, activators

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