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Matrix metalloproteinase-8 (MMP-8) is a member of the peptidase M1A family. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in dгυg development.
MMP-8 plays essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects.
The recombinant human MMP8 consists of 458 amino acids after removal of the signal peptide. A DNA sequence encoding the human MMP8 (Met 1-Gly 467) was expressed with a polyhistidine tag at the C-terminus.
Measured by its ability to cleave the fluorogenic peptide substrate (Mca-PLGL-Dpa-AR-NH2), the specific activity is > 250 pmoles/min/μg.
Activation description: The proenzyme needs to be activated by APMA for an activated form.
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 65-75 kDa, reducing conditions
Lyophilized from sterile 50mM Tris, 10mM CaCl2, 150mM NaCl, pH 7.5.
| Form | Lyophilized powder |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Related Enzymes & Regulators Products |
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| Recombinant Human MAPK8 Protein (E. coli, N-His)
MAPK8 is a multifunctional serine/threonine protein kinase that complexly regulates multiple cellular processes, including cell proliferation, apoptosis, and differentiation. MAPK8 is activated by MAP2K4/MKK4 and MAP2K7/MKK7, phosphorylates AP-1 components, and affects transcriptional activity. |
| Recombinant Human MMP-9 (HEK293, C-6His)
Recombinant human matrix metalloproteinase-9 is produced by a mammalian expression system and the target gene encoding Ala19-Asp707 has a 6His tag at the C-terminus. The proenzyme needs to be activated by APMA to form the active form. Protein ID: AAH06093.1. |
| Recombinant Human MMP-3 (HEK293, C-6His)
MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes. Recombinant Human Matrix Metalloproteinase-3 is produced by Mammalian expression system and the target gene encoding Tyr18-Cys477 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by Chymotrypsin for an activated form. |
| Recombinant Human MMP-1 (HEK293, C-6His)
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens. The target gene encoding Phe20-Asn469 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by APMA for an activated form. |
| Recombinant Human MMP-2 Protein (HEK293, C-6His)
Recombinant Human MMP-2 (also known as matrix metalloproteinase-2) is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. MMP-2 can act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. The proenzyme needs to be activated by APMA for an activated form. |
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