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Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-specific chemokine 3 (MCP-3). CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, within a large cluster containing many other CC chemokines and is most closely related to CCL2. CCL7 can signal through the CCR1, CCR2 and CCR3 receptors.
Recombinant Human MCP‑3/CCL7 expressed the target gene encoding Gln34-Leu109.
The EC50 value of human MCP‑3/CCL7 on Ca2+ mobilization assay in CHO-K1/ Gα15/hCCR1 cells (human Gα15 and human CCR1 stably expressed in CHO-K1 cells) is less than 1.5 μg/ml.
Accession: Q7Z7Q8
Apparent Molecular Weight: 10~18 kDa, under reducing conditions
Endotoxin < 0.2 EU/µg
Lyophilized from sterile PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[2] C Blanpain, et al. Blood. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist
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